Hexachlorocyclotriphosphazene Catalyzed One-Pot Multicomponent Synthesis of 2,3-Dihydro-1H-1,5-benzodiazepines

Sadhna Sharda1, Deo Nandan Prasad1, Sahil Kumar2 and Rajesh K. Singh1,*

1Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140126, India

2Department of Pharmacy, School of Medical and Allied Sciences, G.D. Goenka University, Gurugram- 122103, India

*To whom correspondence to be addressed: E-mail: [email protected]

Abstract

A hexachlorocyclotriphosphazene (HCCP) catalyzed new method has been developed for the synthesis of 2,3-dihydro-1H-1,5-benzodiazepines by cyclocondensation of o-phenylenediamine with aromatic aldehydes or ketones in acetonitrile at room temperature. This protocol is developed as a clean and safe method utilizing environmentalfriendly and highly efficient catalyst.

Keywords

2,3-Dihydro-1H-1,5-benzodiazepines, Hexachlorocyclotriphosphazene, o-Phenylenediamine, Aromatic aldehydes/ketones, Acetonitrile

  
 
  • Asian J. Org. Med. Chem./
  •  2018 /
  •  3(4) /
  •  pp 176-180
  • DOI:10.14233/ajomc.2018.AJOMC-P151